000 03802nam a22005895i 4500
001 978-3-642-05420-4
003 DE-He213
005 20141014113540.0
007 cr nn 008mamaa
008 100301s2010 gw | s |||| 0|eng d
020 _a9783642054204
_9978-3-642-05420-4
024 7 _a10.1007/978-3-642-05420-4
_2doi
041 _aeng
050 4 _aR856-857
072 7 _aMQW
_2bicssc
072 7 _aTEC009000
_2bisacsh
082 0 4 _a610.28
_223
100 1 _aRubinsky, Boris.
_eeditor.
245 1 0 _aIrreversible Electroporation
_h[electronic resource] /
_cedited by Boris Rubinsky.
260 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2010.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2010.
300 _aXIV, 313 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSeries in Biomedical Engineering,
_x1864-5763
505 0 _aHistorical Review of Irreversible Electroporation in Medicine -- Tissue Electroporation as a Bioelectric Phenomenon: Basic Concepts -- Experimental Studies on Irreversible Electroporation of Cells -- Mechanism of Irreversible Electroporation in Cells: Insight from the Models -- Thermal Aspects of Irreversible Electroporation -- Experimental Studies on Non-thermal Irreversible Electroporation in Tissue -- Finite Element Modeling of in Vivo Electroporation -- Optimization and Numerical Modeling in Irreversible Electroporation Treatment Planning -- The Place of the Electroporation-Based Antitumor Therapies in the Electrical Armamentarium against Cancer -- Irreversible Electroporation: First Patient Experience Focal Therapy of Prostate Cancer -- Human Experience with Irreversible Electroporation -- Irreversible Electroporation Systems for Clinical Use -- The Use of Irreversible Electroporation in Food Preservation.
520 _aThis is an brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabilization of the cell membrane, presumable through the formation of nanoscale defects in the cell membrane. Sometimes this process leads to cell death, primarily when the electrical fields cause permanent permeabilization of the membrane and the consequent loss of cell homeostasis, in a process known as irreversible electroporation. This is an unusual mode of cell death that is not fully understood yet. While the phenomenon of irreversible electroporation may have been known for centuries it has become only recently rigorously considered in medicine for various applications of tissue ablation. A brief historical perspective of irreversible electroporation is presentedfollowed by general reviews on the theory and experiment fundamentals and by reports on the most recent theoretical, experimental and clinical studies.
650 0 _aEngineering.
650 0 _aOncology.
650 0 _aCytology.
650 0 _aElectrophoresis.
650 0 _aPhysiology
_xMathematics.
650 0 _aMicrowaves.
650 0 _aBiomedical engineering.
650 1 4 _aEngineering.
650 2 4 _aBiomedical Engineering.
650 2 4 _aElectrophoresis.
650 2 4 _aOncology.
650 2 4 _aCell Biology.
650 2 4 _aPhysiological, Cellular and Medical Topics.
650 2 4 _aMicrowaves, RF and Optical Engineering.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642054198
830 0 _aSeries in Biomedical Engineering,
_x1864-5763
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-05420-4
912 _aZDB-2-ENG
942 _cEB
999 _c3751
_d3751