Mushegian, Arcady R.

Foundations of comparative genomics [electronic resource] / Arcady R. Mushegian. - Amsterdam ; Boston : Academic Press, c2007. - 1 online resource (ix, 265 p.) : ill.

Includes bibliographical references (p. 238-257) and index.

The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology.

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. * Presents an historic overview of genome biology and its achievements * Includes topics not covered in other books such as minimal and ancestral genomes * Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level * Critically reviews horizontal gene transfer and other contentious issues * Covers comparative virology as a somewhat overlooked foundation of modern genome science.

9780120887941 0120887940 9780080546094 (electronic bk.) 0080546099 (electronic bk.)

112454:112542 Elsevier Science & Technology http://www.sciencedirect.com

DNLM


Genomics.
Gene mapping.
Physiology, Comparative.
Genomics--methods.
Genetic Techniques.
Sequence Analysis--methods.
SCIENCE--Life Sciences--Genetics & Genomics.


Electronic books.

QH447 / .M88 2007eb

572.8/6

QH447 / .M88 2007

QU 58.5 / M987f 2007

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