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The complement factsbook [electronic resource] / Bernard J. Morley, Mark J. Walport.

By: Morley, Bernard JContributor(s): Walport, MarkMaterial type: Text

TextSeries: Factsbook series: Publisher: San Diego, CA : Academic Press, c2000Description: 1 online resource (viii, 228 p.) : illISBN: 9780127333601; 0127333606; 9781435610217 (electronic bk.); 1435610210 (electronic bk.); 0080529550; 9780080529554Subject(s): Complement (Immunology) | MEDICAL -- Immunology | Complement System Proteins -- geneticsGenre/Form: Electronic books.Additional physical formats: Print version:: Complement factsbook.DDC classification: 616.07/997 LOC classification: QR185.8.C6 | M675 2000ebOnline resources: ScienceDirect

Contents:

Abbreviations. -- Preface. -- Section 1: The Introductory Chapters -- B.J. Morley and M. Walport, Introduction. -- B.J. Morely and M. Walport, The Complement System. -- Section II: The Complement Proteins -- Part 1: C1q and the Collections -- F. Petry and M. Loos, C1q. -- P. Lawson and K.B.M. Reid, Mannose-binding Lectin. -- P. Lawson and K.B.M. Reid, Bovine Conglutinin. -- R.B. Sim, SP-A. -- R.B. Sim, SP-D. -- Part 2: Serine Proteases -- N. Thielens and G.J. Arlaud, C1r. -- N. Thielens and G.J. Arlaud, C1s. -- T. Fujita, MASP-1. -- S. Petersen and J. Jensenius, MASP-2. -- J. Schifferli and S. Niot, Factor D. -- Y. Xu Ma and J.E. Volanakis, C2. -- A. Circolo and H.R. Colten, Factor B. -- B.J. Morley, Factor I. -- Part 3: C3 Family -- M. Botto, C3. -- R.A. Wetsel, C5. -- Part 4: Terminal Pathway Components -- M. Hobart, C6. -- M. Hobart, C7. -- F. Tedesco, M.E. Plumb, and J.M. Sodetz, C8. -- B.P. Morgan, C9. -- Part 5: Regulations of Complement Activation (RCA) -- L.B. Klickstein, CR1. -- J.M. Guthridge and V.M. Holers, CR2. -- L. Kuttner-Kondo, W.G. Brodbeck, and M.E. Medof, Decay-accelerating Factor. -- M.K. Liszewski and J.P. Atkinson, Membrane Cofactor Protein. -- S. Rodriguez de Cordoba, O. Criado Garcia, and P. Sanchez-Corral, C4b-binding Protein. -- R.G. DiScipio, Factor H. -- Part 6: Cell Surface Receptors -- A.J. Tenner, C1qRp. -- R.S. Ames, C3aReceptor. -- A. Klos and W. Bautsch, C5a Receptor. -- Y. Xia and G. Ross, CR3. -- A. Law, CR4. -- Part 7: Miscellaneous Complement Components -- R. Zahedi and A.E. Davis III, C1 Inhibitor. -- M.E. Rosenberg, Apolipoprotein J (Clusterin). -- T. Farries, Properdin. -- B.P. Morgan, CD59. -- Index.

Summary: The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Key Features * Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies * Presents detailed structural information including cDNA and gene structure for all proteins * Introduces complement function, simply described for each function * Data is as up-to-date as possible, including unpublished work from many contributors * Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families * Each chapter has been written by an expert in the field * Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: * Alternative nomenclature * Physiochemical properties * Structure and function * Tissue distribution and regulation expression * Protein sequence/modules * Chromosomal location * Genomic structure * Database accession numbers * Deficiency and polymorphic variants * Key references.

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Includes index.

Includes bibliographical references and index.

The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Key Features * Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies * Presents detailed structural information including cDNA and gene structure for all proteins * Introduces complement function, simply described for each function * Data is as up-to-date as possible, including unpublished work from many contributors * Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families * Each chapter has been written by an expert in the field * Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: * Alternative nomenclature * Physiochemical properties * Structure and function * Tissue distribution and regulation expression * Protein sequence/modules * Chromosomal location * Genomic structure * Database accession numbers * Deficiency and polymorphic variants * Key references.

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