Genetic recombination in cancer [electronic resource] / G.V. Sherbet.

By: Sherbet, G. V. (Gajanan V.)Material type: TextTextPublisher: San Diego, Calif. ; London : Academic, 2003Description: 1 online resource (304 p.) : illISBN: 9780126398816; 012639881XSubject(s): Cancer -- Genetic aspects | Genetic recombination | Neoplasms -- genetics | Neoplasm Metastasis | Recombination, GeneticGenre/Form: Electronic books.Additional physical formats: Print version:: Genetic recombination in cancer.DDC classification: 616.994042 LOC classification: RC268.4 | .S465 2003ebOnline resources: ScienceDirect
Contents:
Genetic Integrity, DNA Repair and Recombination -- Replication Error (RER) and Genetic Instability -- DNA Repeats, Genetic Recombination and the Pathogenesis of Genetic Disorders -- Chromosomal Recombination in Cancer -- Chromosomal Translocation and its Phenotypic Outcome -- DNA Methylation and Genetic Instability -- Telomeric DNA and Genetic Instability.
Summary: Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers.
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Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers.

Genetic Integrity, DNA Repair and Recombination -- Replication Error (RER) and Genetic Instability -- DNA Repeats, Genetic Recombination and the Pathogenesis of Genetic Disorders -- Chromosomal Recombination in Cancer -- Chromosomal Translocation and its Phenotypic Outcome -- DNA Methylation and Genetic Instability -- Telomeric DNA and Genetic Instability.

Includes bibliographical references and index.

Description based on print version record.

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