Advances in DNA sequence specific agents [electronic resource] / series editor, Graham B. Jones ; volume editor, Brant J. Chapman.Material type: TextSeries: Advances in DNA sequence specific agents: v. 4.Publisher: Amsterdam, the Netherlands : Elseview Science B.V., c2002Edition: 1st edDescription: 1 online resource (viii, 151 p.) : illISBN: 9780444510969; 0444510966; 9780080526133 (electronic bk.); 0080526136 (electronic bk.)Subject(s): DNA | Nucleotide sequence | DNA | Sequence Analysis, DNA | SCIENCE -- Life Sciences -- Genetics & GenomicsGenre/Form: Electronic books.Additional physical formats: Print version:: Advances in DNA sequence specific agents.DDC classification: 572.8/633 LOC classification: QP624 | .A38 2002Online resources: ScienceDirect
This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series. Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology. Features include: & bull; Expert contributors from the Biomedical world & bull; Emerging areas of drug design and therapeutic applications & bull; Nucleic acid-protein interactions & bull; Color graphics of molecular modeling analyses & bull; New and emerging methodologies.
Includes bibliographical references.
Description based on print version record.
Front Cover; Advance in DNA Sequence-Specific Agents; Copyright Page; Contents; Preface; Chapter 1. Preferential damage to defined regions of genomic DNA by AT-specific anticancer drugs; Chapter 2. DNA-alkylating events associated with nitrogen mustard based anticancer drugs and the metabolic by product Acrolein; Chapter 3. Molecular basis for recognition and binding of specific DNA sequences by calicheamicin and duocarmycin; Chapter 4. Enediyne antibiotic neocarzinostatin as a radical-based probe of bulged structures in nucleic acids