Advances in DNA sequence specific agents [electronic resource] : a research annual. Volume 2 / editor Laurence H. Hurley.

Contributor(s): Hurley, Laurence H [�ed.]Material type: TextTextSeries: Advances in DNA sequence specific agents ; vol. 2Publisher: Greenwich (Connecticut) ; London : Jai Press, 1996Description: 1 online resource (xi, 347 p.) : illISBN: 9781559381666; 1559381663Subject(s): Nucleotide sequence | DNA | Molecular recognition | ADN | G�en�etique biochimique | G�enie g�en�etiqueGenre/Form: Electronic books.Additional physical formats: Print version:: Advances in DNA sequence specific agents.; Online version:: Advances in DNA sequence specific agents Volume 2.DDC classification: 572.8/633 LOC classification: QP625.N89 | A38 1996Online resources: ScienceDirect
Contents:
List of Contributors. Preface Part I: Methods used to evaluate the molecular basis for sequence specificity. Part II: Sequence Specificity of DNA Interactive Drugs.
Summary: DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of <IT>Advances in DNA Sequence Specific Agents</IT>. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.
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DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of <IT>Advances in DNA Sequence Specific Agents</IT>. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

List of Contributors. Preface Part I: Methods used to evaluate the molecular basis for sequence specificity. Part II: Sequence Specificity of DNA Interactive Drugs.

Bibliogr. Index.

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