Peptides [electronic resource] : synthesis, structures, and applications / edited by Bernd Gutte.

Contributor(s): Gutte, BerndMaterial type: TextTextPublisher: San Diego : Academic Press, c1995Description: 1 online resource (xiv, 511 p.) : illISBN: 9780123109200; 0123109205; 9780080538594 (electronic bk.); 0080538592 (electronic bk.)Subject(s): Peptides | Peptides -- Synthesis | Peptides -- Structure | Peptides | SCIENCE -- Life Sciences -- Biochemistry | Peptiden | Structuur-activiteit-relatie | Synthese (chemie) | Hormonen | Polypeptiden | PeptidesGenre/Form: Electronic books.Additional physical formats: Print version:: Peptides.DDC classification: 574.19/2456 LOC classification: QP552.P4 | P487 1995ebOnline resources: ScienceDirect
Contents:
The history of peptide chemistry / Theodor Wieland -- Amide formation, deprotection, and disulfide formation in peptide synthesis / Yoshiaki Kiso and Haruaki Yajima -- Solid-phase peptide synthesis / Bruce Merrifield -- [alpha]-helix formation by peptides in water / J. Martin Scholtz and Robert L. Baldwin -- Peptide conformation : stability and dynamics / Garland R. Marshall, Denise D. Beusen, and Gregory V. Nikiforovich -- Structure-function studies of peptide hormones : an overview / Victor J. Hruby and Dinesh Patel -- Neuropeptides : peptide and nonpeptide analogs / Andrzej W. Lipkowski and Daniel B. Carr -- Reversible inhibitors of serine proteinases : naturally occurring miniproteins, semisynthetic variants, recombinant homologs, and synthetic peptides / Herbert R. Wenzel and Harald Tschesche -- Design of polypeptides / Bernd Gutte and Stephan Klauser -- Soluble chemical combinatorial libraries : current capabilities and future possibilities / Richard A. Houghten -- Epitope mapping with peptides / Hans Rudolf Bosshard -- Synthesis and applications of branched peptides in immunological methods and vaccines / James P. Tam.
Summary: In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. Coverage includes: * The history of peptide chemistry * Amide formation, deprotection, and disulfide formation in peptide synthesis * Solid-phase peptide synthesis * a-helix formation by peptides in water * Stability and dynamics of peptide conformation * An overview of structure-function studies of peptide hormones * Neuropeptides:peptide and nonpeptide analogs * Reversible inhibitors of serine proteinases * Design of polypeptides * Current capabilities and future possibilities of soluble chemical combinatorial libraries * Epitope mapping with peptides * Synthesis and applications of branched peptides in immunological methods and vaccines.
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Includes bibliographical references and index.

The history of peptide chemistry / Theodor Wieland -- Amide formation, deprotection, and disulfide formation in peptide synthesis / Yoshiaki Kiso and Haruaki Yajima -- Solid-phase peptide synthesis / Bruce Merrifield -- [alpha]-helix formation by peptides in water / J. Martin Scholtz and Robert L. Baldwin -- Peptide conformation : stability and dynamics / Garland R. Marshall, Denise D. Beusen, and Gregory V. Nikiforovich -- Structure-function studies of peptide hormones : an overview / Victor J. Hruby and Dinesh Patel -- Neuropeptides : peptide and nonpeptide analogs / Andrzej W. Lipkowski and Daniel B. Carr -- Reversible inhibitors of serine proteinases : naturally occurring miniproteins, semisynthetic variants, recombinant homologs, and synthetic peptides / Herbert R. Wenzel and Harald Tschesche -- Design of polypeptides / Bernd Gutte and Stephan Klauser -- Soluble chemical combinatorial libraries : current capabilities and future possibilities / Richard A. Houghten -- Epitope mapping with peptides / Hans Rudolf Bosshard -- Synthesis and applications of branched peptides in immunological methods and vaccines / James P. Tam.

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. Coverage includes: * The history of peptide chemistry * Amide formation, deprotection, and disulfide formation in peptide synthesis * Solid-phase peptide synthesis * a-helix formation by peptides in water * Stability and dynamics of peptide conformation * An overview of structure-function studies of peptide hormones * Neuropeptides:peptide and nonpeptide analogs * Reversible inhibitors of serine proteinases * Design of polypeptides * Current capabilities and future possibilities of soluble chemical combinatorial libraries * Epitope mapping with peptides * Synthesis and applications of branched peptides in immunological methods and vaccines.

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