Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol-linked proteins [electronic resource] / edited by Neal S. Young, Joel Moss.

Contributor(s): Young, Neal S | Moss, JoelMaterial type: TextTextPublisher: San Diego : Academic Press, c2000Description: 1 online resource (xiii, 279 p.) : ill. (some col.)ISBN: 9780127729404; 0127729402; 9780080492094 (electronic bk.); 0080492096 (electronic bk.)Other title: PNH and the GPI-linked proteinsSubject(s): Paroxysmal hemoglobinuria | Phosphoinositides | Glycoproteins | Membrane proteins | Cellular signal transduction | Hemoglobinuria, Paroxysmal | Glycoproteins | Glycosylphosphatidylinositols | MEDICAL -- HematologyGenre/Form: Electronic books.Additional physical formats: Print version:: Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol-linked proteins.DDC classification: 616.1/51 LOC classification: RC641.7.P37 | P37 2000ebOnline resources: ScienceDirect
Contents:
Front Cover; Paroxysmal Nocturnal Hemoglobinuria and the Glycosylphosphatidylinositol- Linked Proteins; Copyright Page; Contents; Contributors; Preface; Chapter 1. A Brief History of PNH; Chapter 2. Genetics of PNH; Chapter 3. Hemolysis in PNH; Chapter 4. Thrombotic Complications in PNH; Chapter 5. Bone Marrow Failure in PNH; Chapter 6. Animal Models of PNH; Chapter 7. The Function of GPI-Anchored Proteins; Chapter 8. GPI in Lower Animals; Chapter 9. Synthesis of the GPI Anchor; Chapter 10. Functional and Structural Organization of GPI-Anchored Proteins in Cellular Membranes
Summary: Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Key Features * Outlines the chemical features of PNH * Explains the mechanism of hemolysis * Includes work on the biochemistry of glycophosphoinositol anchors * Contains descriptions of the chemistry and biophysics of GPI-anchored proteins.
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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Key Features * Outlines the chemical features of PNH * Explains the mechanism of hemolysis * Includes work on the biochemistry of glycophosphoinositol anchors * Contains descriptions of the chemistry and biophysics of GPI-anchored proteins.

Includes bibliographical references and index.

Description based on print version record.

Front Cover; Paroxysmal Nocturnal Hemoglobinuria and the Glycosylphosphatidylinositol- Linked Proteins; Copyright Page; Contents; Contributors; Preface; Chapter 1. A Brief History of PNH; Chapter 2. Genetics of PNH; Chapter 3. Hemolysis in PNH; Chapter 4. Thrombotic Complications in PNH; Chapter 5. Bone Marrow Failure in PNH; Chapter 6. Animal Models of PNH; Chapter 7. The Function of GPI-Anchored Proteins; Chapter 8. GPI in Lower Animals; Chapter 9. Synthesis of the GPI Anchor; Chapter 10. Functional and Structural Organization of GPI-Anchored Proteins in Cellular Membranes

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