Metabolic engineering [electronic resource] : principles and methodologies / Gregory N. Stephanopoulos, Aristos A. Aristidou, Jens Nielsen.

By: Stephanopoulos, GContributor(s): Aristidou, Aristos A | Nielsen, Jens H�iriisMaterial type: TextTextPublisher: San Diego : Academic Press, c1998Description: 1 online resource (xxi, 725 p.) : illISBN: 9780126662603; 0126662606; 9780080536286 (electronic bk.); 008053628X (electronic bk.)Subject(s): Biochemical engineering | Metabolism | Metabolism | Biochemistry | Metabolieten | Moleculaire genetica | Celbiologie | Biosynthese | Metabolismo | Bioquimica | Engenharia quimica | SCIENCE -- BiotechnologyGenre/Form: Electronic books.Additional physical formats: Print version:: Metabolic engineering.DDC classification: 660.6/3 LOC classification: TP248.3 | .S74 1998ebOnline resources: ScienceDirect
Contents:
The Essence of Metabolic Engineering. Review of Cellular Metabolism. Comprehensive Models for Cellular Reactions. Material Balances and Data Consistency. Regulation of Metabolic Pathways. Examples of Pathway Manipulations: Metabolic Engineering in Practice. Metabolic Pathway Synthesis. Metabolic Flux Analysis. Methods for the Experimental Determination of Metabolic Fluxes by Isotope Labeling. Applications of Metabolic Flux Analysis. Metabolic Control Analysis. Analysis of Structure of Metabolic Networks. Flux Analysis of Metabolic Networks. Thermodynamics of Cellular Processes. Glossary. Subject Index.
1. The essence of metabolic engineering -- 2. Review of cellular metabolism -- 3. Comprehensive models for cellular reactions -- 4. Material balances and data consistency -- 5. Regulation of metabolic pathways -- 6. Examples of pathway manipulations : metabolic engineering in practice -- 7. Metabolic pathway synthesis -- 8. Metabolic flux analysis -- 9. Methods for the experimental determination of metabolic fluxes by isotope labeling -- 10. Applications of metabolic flux analysis -- 11. Metabolic control analysis -- 12. Analysis of structure of metabolic networks -- 13. Flux analysis of metabolic networks -- 14. Thermodynamics of cellular processes.
Summary: Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes. Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems. Key Features * Demonstrates metabolic engineering in action with numerous examples of pathway modification * Includes methods for identifying key enzymes in metabolic networks * Contains a comprehensive review of metabolic biochemistry * Discusses metabolic regulation at the gene, enzyme, operon, and cell levels * Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways * Minimizes mathematical complexity * Links to a Web page to communicate updates of the software code and homework problems.
Tags from this library: No tags from this library for this title. Log in to add tags.
    Average rating: 0.0 (0 votes)
No physical items for this record

Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes. Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems. Key Features * Demonstrates metabolic engineering in action with numerous examples of pathway modification * Includes methods for identifying key enzymes in metabolic networks * Contains a comprehensive review of metabolic biochemistry * Discusses metabolic regulation at the gene, enzyme, operon, and cell levels * Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways * Minimizes mathematical complexity * Links to a Web page to communicate updates of the software code and homework problems.

The Essence of Metabolic Engineering. Review of Cellular Metabolism. Comprehensive Models for Cellular Reactions. Material Balances and Data Consistency. Regulation of Metabolic Pathways. Examples of Pathway Manipulations: Metabolic Engineering in Practice. Metabolic Pathway Synthesis. Metabolic Flux Analysis. Methods for the Experimental Determination of Metabolic Fluxes by Isotope Labeling. Applications of Metabolic Flux Analysis. Metabolic Control Analysis. Analysis of Structure of Metabolic Networks. Flux Analysis of Metabolic Networks. Thermodynamics of Cellular Processes. Glossary. Subject Index.

Includes bibliographical references and index.

1. The essence of metabolic engineering -- 2. Review of cellular metabolism -- 3. Comprehensive models for cellular reactions -- 4. Material balances and data consistency -- 5. Regulation of metabolic pathways -- 6. Examples of pathway manipulations : metabolic engineering in practice -- 7. Metabolic pathway synthesis -- 8. Metabolic flux analysis -- 9. Methods for the experimental determination of metabolic fluxes by isotope labeling -- 10. Applications of metabolic flux analysis -- 11. Metabolic control analysis -- 12. Analysis of structure of metabolic networks -- 13. Flux analysis of metabolic networks -- 14. Thermodynamics of cellular processes.

Description based on print version record.

There are no comments on this title.

to post a comment.

Implemented and Maintained by Biju Patnaik Central Library.
For any Suggestions/Query Contact to library or Email: library@nitrkl.ac.in OR bpcl-cir@nitrkl.ac.in. Ph:91+6612462103
Website/OPAC best viewed in Mozilla Browser in 1366X768 Resolution.

Powered by Koha