Systems biology [electronic resource] : philosophical foundations / edited by Fred C. Boogerd ... [et al.].

Contributor(s): Boogerd, Fred CMaterial type: TextTextPublisher: Amsterdam ; Boston : Elsevier, 2007Edition: 1st edDescription: 1 online resource (xviii, 342 p.) : illISBN: 9780444520852; 0444520856; 9780080475271 (electronic bk.); 0080475272 (electronic bk.)Subject(s): Biology -- Philosophy | Biological systems | Biological models | NATURE -- Reference | SCIENCE -- Life Sciences -- General | SCIENCE -- Life Sciences -- Biology | Systeemtheorie | Theoretische biologie | WetenschapsfilosofieGenre/Form: Electronic books.Additional physical formats: Print version:: Systems biology.DDC classification: 570.1 LOC classification: QH331 | .S96 2007ebOther classification: 42.10 Online resources: ScienceDirect
Contents:
Introduction -- 1. Towards philosophical foundations of Systems Biology: Introduction -- Research programs of Systems Biology -- 2. The methodologies of Systems Biology -- 3. Methodology is Philosophy -- 4. How can we understand metabolism? -- 5. On Building Reliable Pictures with Unreliable Data: an Evolutionary and Developmental Coda for the New Systems Biology? -- Theory / models -- 6. Mechanism and mechanical explanation in cell biology -- 7. Theories, Models, and Equations in Systems Biology -- 8. All models are wrong ... some more than others -- 9. Data without models merging with models without data -- Organization in biological systems -- 10. The biochemical factory that autonomously fabricates itself: a systems-biological view of the living cell -- 11. A systemic approach to the origin of biological organization -- 12. Organization and biological mechanisms: organized to maintain autonomy -- 13. The disappearance of function from 'self-organizing systems' -- Conclusion -- 14. Afterthoughts as foundations for Systems Biology.
Summary: Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system.
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Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system.

Introduction -- 1. Towards philosophical foundations of Systems Biology: Introduction -- Research programs of Systems Biology -- 2. The methodologies of Systems Biology -- 3. Methodology is Philosophy -- 4. How can we understand metabolism? -- 5. On Building Reliable Pictures with Unreliable Data: an Evolutionary and Developmental Coda for the New Systems Biology? -- Theory / models -- 6. Mechanism and mechanical explanation in cell biology -- 7. Theories, Models, and Equations in Systems Biology -- 8. All models are wrong ... some more than others -- 9. Data without models merging with models without data -- Organization in biological systems -- 10. The biochemical factory that autonomously fabricates itself: a systems-biological view of the living cell -- 11. A systemic approach to the origin of biological organization -- 12. Organization and biological mechanisms: organized to maintain autonomy -- 13. The disappearance of function from 'self-organizing systems' -- Conclusion -- 14. Afterthoughts as foundations for Systems Biology.

Includes bibliographical references and index.

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