Advances in DNA sequence specific agents (Record no. 202)

000 -LEADER
fixed length control field 04419cam a2200505Ia 4500
001 - CONTROL NUMBER
control field ocn162130678
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140426153708.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cn|
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 070802s1998 ctua ob 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency OPELS
Language of cataloging eng
Transcribing agency OPELS
Modifying agency OPELS
-- OCLCQ
-- OCLCE
-- OCLCQ
-- GBVCP
019 ## -
-- 760073434
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780762302031
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 0762302038
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 12432826
029 1# - (OCLC)
OCLC library identifier AU@
System control number 000048130734
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV039829057
029 1# - (OCLC)
OCLC library identifier GBVCP
System control number 58845415X
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)162130678
Canceled/invalid control number (OCoLC)760073434
037 ## - SOURCE OF ACQUISITION
Stock number 120954:127997
Source of stock number/acquisition Elsevier Science & Technology
Note http://www.sciencedirect.com
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QP625.N89
Item number A38 1998
060 #0 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER
Classification number QH 431
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 572.8/633
Edition number 22
049 ## - LOCAL HOLDINGS (OCLC)
Holding library NTRA
245 00 - TITLE STATEMENT
Title Advances in DNA sequence specific agents
Medium [electronic resource] :
Remainder of title a research annual.
Number of part/section of a work Volume 3 /
Statement of responsibility, etc editor Laurence H. Hurley.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc Greenwich (Connecticut) ;
-- London :
Name of publisher, distributor, etc Jai Press,
Date of publication, distribution, etc 1998.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (x, 283 p.) :
Other physical details ill.
520 ## - SUMMARY, ETC.
Summary, etc In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface. Introduction to DNA Sequence-specific agents . Sequence-specific poisons of type II DNA topoisomerases. Topoisomerase I-targeting drugs: new developments in cancer pharmacology. DNA sequence recognition altered BIS-benzimidazole minor-groove binders. Sequence-specific recognition and modification of double-helical DNA by minor-groove binding conjugates structurally related to netropsin and distamycin. New developments in the use of nitrogen mustard alkylating agents as anticancer drugs. DNA binding of nonclassical platinum antitumor complexes. Kedarcidin and maduropeptin: two novel antitumor chromoproteins with selective protease activity and DNA cleaving properties. Antisense- and antigene-based drug design strategies in oncology. Sequence-specific recognition of double-stranded DNA by peptide nucleic acids.
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Bibliogr. Index.
588 ## -
-- Description based on print version record.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Nucleotide sequence.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Molecular biology.
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element ADN.
Source of heading or term fmesh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element G�en�etique biochimique.
Source of heading or term fmesh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element G�enie g�en�etique.
Source of heading or term fmesh
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Hurley, Laurence H.,
Relator term �ed.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Advances in DNA sequence specific agents.
Place, publisher, and date of publication Greenwich (Connecticut) ; London : Jai Press, 1998
International Standard Book Number 0762302038
-- 9780762302031
Record control number (OCoLC)40941431
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Online version:
Title Advances in DNA sequence specific agents Volume 3.
Place, publisher, and date of publication Greenwich (Connecticut) ; London : Jai Press, 1998
Record control number (OCoLC)760073434
856 40 - ELECTRONIC LOCATION AND ACCESS
Materials specified ScienceDirect
Uniform Resource Identifier http://www.sciencedirect.com/science/book/9780762302031
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type E-Books
994 ## -
-- 92
-- NITR

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