Ion channels and disease (Record no. 121)

000 -LEADER
fixed length control field 05182cam a2200697Ia 4500
001 - CONTROL NUMBER
control field ocn162128696
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20140426153706.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cn|
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 070802s2000 caua ob 001 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency OPELS
Language of cataloging eng
Transcribing agency OPELS
Modifying agency OCLCQ
-- N$T
-- YDXCP
-- IDEBK
-- OCLCQ
-- TULIB
-- OCLCO
-- EBLCP
-- OCLCQ
-- GBVCP
019 ## -
-- 171132678
-- 173610112
-- 779916746
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780120653102
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 0120653109
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781435601123 (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 1435601122 (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 0080535216
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780080535210
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 12432253
029 1# - (OCLC)
OCLC library identifier AU@
System control number 000048130650
029 1# - (OCLC)
OCLC library identifier GBVCP
System control number 588455296
029 1# - (OCLC)
OCLC library identifier AU@
System control number 000051330194
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)162128696
Canceled/invalid control number (OCoLC)171132678
-- (OCoLC)173610112
-- (OCoLC)779916746
037 ## - SOURCE OF ACQUISITION
Stock number 77892:77892
Source of stock number/acquisition Elsevier Science & Technology
Note http://www.sciencedirect.com
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RB112.5
Item number .A83 2000eb
060 #0 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER
Classification number 1999 K-445
060 #0 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER
Classification number QH 603.I54
070 ## - NATIONAL AGRICULTURAL LIBRARY CALL NUMBER
Classification number QH603.I54
Item number A84 2000
072 #0 - SUBJECT CATEGORY CODE
Subject category code X300
072 #0 - SUBJECT CATEGORY CODE
Subject category code L840
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED
Subject category code subdivision 067000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED
Subject category code subdivision 068000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 616.07
Edition number 22
049 ## - LOCAL HOLDINGS (OCLC)
Holding library NTRA
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Ashcroft, Frances M.
245 10 - TITLE STATEMENT
Title Ion channels and disease
Medium [electronic resource] :
Remainder of title channelopathies /
Statement of responsibility, etc Frances M. Ashcroft.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc San Diego :
Name of publisher, distributor, etc Academic Press,
Date of publication, distribution, etc c2000.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (xxi, 481 p.) :
Other physical details ill. (some col.)
520 ## - SUMMARY, ETC.
Summary, etc Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references (p. 419-464) and index.
588 ## -
-- Description based on print version record.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Ion channels.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Pathology, Molecular.
650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Ion Channels
General subdivision physiology.
650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Genetic Diseases, Inborn
General subdivision physiopathology.
650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Membrane Proteins
General subdivision physiology.
650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Metabolism, Inborn Errors
General subdivision physiopathology.
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element MEDICAL
General subdivision Pathology.
Source of heading or term bisacsh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element MEDICAL
General subdivision Pathophysiology.
Source of heading or term bisacsh
650 17 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Kanalopathie´┐Żen.
Source of heading or term gtt
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Main entry heading Ashcroft, Frances M.
Title Ion channels and disease.
Place, publisher, and date of publication San Diego : Academic Press, c2000
International Standard Book Number 0120653109
-- 9780120653102
Record control number (DLC) 98085618
-- (OCoLC)42686352
856 40 - ELECTRONIC LOCATION AND ACCESS
Materials specified ScienceDirect
Uniform Resource Identifier http://www.sciencedirect.com/science/book/9780120653102
938 ## -
-- YBP Library Services
-- YANK
-- 2712329
938 ## -
-- EBL - Ebook Library
-- EBLB
-- EBL306685
938 ## -
-- EBSCOhost
-- EBSC
-- 141522
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type E-Books
994 ## -
-- 92
-- NITR

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