Ion channels and disease (Record no. 121)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05182cam a2200697Ia 4500 |
| 001 - CONTROL NUMBER | |
| control field | ocn162128696 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140426153706.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cn| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 070802s2000 caua ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | OPELS |
| Language of cataloging | eng |
| Transcribing agency | OPELS |
| Modifying agency | OCLCQ |
| -- | N$T |
| -- | YDXCP |
| -- | IDEBK |
| -- | OCLCQ |
| -- | TULIB |
| -- | OCLCO |
| -- | EBLCP |
| -- | OCLCQ |
| -- | GBVCP |
| 019 ## - | |
| -- | 171132678 |
| -- | 173610112 |
| -- | 779916746 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780120653102 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0120653109 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781435601123 (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 1435601122 (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0080535216 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780080535210 |
| 029 1# - (OCLC) | |
| OCLC library identifier | NZ1 |
| System control number | 12432253 |
| 029 1# - (OCLC) | |
| OCLC library identifier | AU@ |
| System control number | 000048130650 |
| 029 1# - (OCLC) | |
| OCLC library identifier | GBVCP |
| System control number | 588455296 |
| 029 1# - (OCLC) | |
| OCLC library identifier | AU@ |
| System control number | 000051330194 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)162128696 |
| Canceled/invalid control number | (OCoLC)171132678 |
| -- | (OCoLC)173610112 |
| -- | (OCoLC)779916746 |
| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 77892:77892 |
| Source of stock number/acquisition | Elsevier Science & Technology |
| Note | http://www.sciencedirect.com |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RB112.5 |
| Item number | .A83 2000eb |
| 060 #0 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | 1999 K-445 |
| 060 #0 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | QH 603.I54 |
| 070 ## - NATIONAL AGRICULTURAL LIBRARY CALL NUMBER | |
| Classification number | QH603.I54 |
| Item number | A84 2000 |
| 072 #0 - SUBJECT CATEGORY CODE | |
| Subject category code | X300 |
| 072 #0 - SUBJECT CATEGORY CODE | |
| Subject category code | L840 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 067000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 068000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.07 |
| Edition number | 22 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | NTRA |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ashcroft, Frances M. |
| 245 10 - TITLE STATEMENT | |
| Title | Ion channels and disease |
| Medium | [electronic resource] : |
| Remainder of title | channelopathies / |
| Statement of responsibility, etc | Frances M. Ashcroft. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | San Diego : |
| Name of publisher, distributor, etc | Academic Press, |
| Date of publication, distribution, etc | c2000. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (xxi, 481 p.) : |
| Other physical details | ill. (some col.) |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references (p. 419-464) and index. |
| 588 ## - | |
| -- | Description based on print version record. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Ion channels. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pathology, Molecular. |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Ion Channels |
| General subdivision | physiology. |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetic Diseases, Inborn |
| General subdivision | physiopathology. |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Membrane Proteins |
| General subdivision | physiology. |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Metabolism, Inborn Errors |
| General subdivision | physiopathology. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL |
| General subdivision | Pathology. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL |
| General subdivision | Pathophysiology. |
| Source of heading or term | bisacsh |
| 650 17 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Kanalopathie�en. |
| Source of heading or term | gtt |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Print version: |
| Main entry heading | Ashcroft, Frances M. |
| Title | Ion channels and disease. |
| Place, publisher, and date of publication | San Diego : Academic Press, c2000 |
| International Standard Book Number | 0120653109 |
| -- | 9780120653102 |
| Record control number | (DLC) 98085618 |
| -- | (OCoLC)42686352 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | ScienceDirect |
| Uniform Resource Identifier | http://www.sciencedirect.com/science/book/9780120653102 |
| 938 ## - | |
| -- | YBP Library Services |
| -- | YANK |
| -- | 2712329 |
| 938 ## - | |
| -- | EBL - Ebook Library |
| -- | EBLB |
| -- | EBL306685 |
| 938 ## - | |
| -- | EBSCOhost |
| -- | EBSC |
| -- | 141522 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | E-Books |
| 994 ## - | |
| -- | 92 |
| -- | NITR |
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